Reaction #1106682

Reaction equation

C-Benzo[1,3]dioxol-2-yl-methylamine

sulfamide

→

title compound

(Benzo[1,3]dioxol-2-ylmethyl)sulfamide

Solvents

dioxane

Conditions

Workup

1. 1
   Temperaturethe solution was heated
2. 2
   Temperatureto reflux overnight
3. 3
   ConcentrationThe reaction was concentrated
4. 4
   Otherthe residue was chromatographed (2% to 10% acetone in dichloromethane)

Procedure

C-Benzo[1,3]dioxol-2-yl-methylamine (2.94 g, 19.4 mmol) and sulfamide (3.74 g, 38.9 mmol) were combined in dry dioxane (50 mL) and the solution was heated to reflux overnight. The reaction was concentrated and the residue was chromatographed (2% to 10% acetone in dichloromethane) to yield the title compound as a white solid.

Source