Reaction #1106612

Reaction equation

2-hydroxy-1-naphthaldehyde

ethanol

2-aminobiphenyl

→

2-hydroxy-1-naphthylmethylidene-2-phenylaniline

Conditions

Workup

1. 1
   Temperatureunder heating
2. 2
   ConcentrationThe solution was concentrated with an evaporator to about 30 ml, whereupon a crystal
3. 3
   Otherwas formed
4. 4
   Filtrationwhich was filtered by Kiriyama funnel
5. 5
   OtherDrying under reduced pressure at 25° C. for 24 hours

Procedure

3.44 g (20.0 mmol) of 2-hydroxy-1-naphthaldehyde was dissolved in 50 ml ethanol under heating, and 3.38 g (20.0 mmol) of 2-aminobiphenyl was added. After stirring under reflux at 70° C. for 1 hour, completion of the reaction was confirmed by TLC. The solution was concentrated with an evaporator to about 30 ml, whereupon a crystal was formed, which was filtered by Kiriyama funnel. Drying under reduced pressure at 25° C. for 24 hours gave 2-hydroxy-1-naphthylmethylidene-2-phenylaniline (hereinafter, also referred to as “HNBP”) as a yellow crystal (5.62 g, 87%).

Source