Reaction #1099100

Reaction equation

[1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone

trans-2-(4-chlorophenyl)vinylboronic acid

→

title compound

Yield 67.0%

(1-{3-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-3,5-dimethyl-1H-pyrazol-4-yl)-(3-diethylamino-pyrrolidin-1-yl)-methanone

Yield 67.0%

Conditions

Procedure

In analogy to the procedure described in Example 14C], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (Example 28A]) and trans-2-(4-chlorophenyl)vinylboronic acid gave the title compound in 67% yield as light brown foam. MS: 477.3 (MH+, 1 Cl).

Source