Reaction #1098645

Reaction equation

fluoroazide

1-Azido-3-fluoropropan-2-ol

1-propynyl-2-nitroimidazole

→

1-Fluoro-3-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-2-ol

Conditions

Workup

1. 1
   OtherThe material is then purified on a silica gel column
2. 2
   OtherThe material is then further purified via recrystallization
3. 3
   OtherHex to afford pale yellow crystals

Procedure

To a vial is added fluoroazide 17 (5.79 mmol) and 1-propynyl-2-nitroimidazole (5.79 mmol). The solution is heated at 60° C. overnight. The material is then purified on a silica gel column using EtOAc:Hex as the eluent. The material is then further purified via recrystallization using EtOAc:Hex to afford pale yellow crystals. Preparation of Compounds 5 and 21:

Source