Reaction #1095847

Reaction equation

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

Solvents

piperidine

dimethylformamide

Conditions

Workup

1. 1
   ConcentrationThe reaction mixture was concentrated under vacuum, water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   Extractionthe product was extracted with ethyl acetate
4. 4
   OtherThe crude product was purified by conversion into its hydrochloride salt

Procedure

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) was dissolved in 20% piperidine in dimethylformamide at 0° C. The solution was continued stifling for 1 h. The reaction mixture was concentrated under vacuum, water was added to the residue, and the product was extracted with ethyl acetate. The crude product was purified by conversion into its hydrochloride salt.

Source