Reaction #1071047

ord-e9f8b7fe27884d8b8e969108146ed08e

Reaction equation

N=C(N)c1ccc(F)cc1Cl
2-chlor-4-fluoro-benzamidine
N#CC(C#N)=Cc1ccc(Cl)cc1Cl
2-(2,4-dichloro-benzylidene)-malononitrile
→
NCc1c(N)nc(-c2ccc(F)cc2Cl)nc1-c1ccc(Cl)cc1Cl
title compound
NCc1c(N)nc(-c2ccc(F)cc2Cl)nc1-c1ccc(Cl)cc1Cl
5-Aminomethyl-2-(2-chloro-4-fluoro-phenyl)-6-(2,4-dichloro-phenyl)-pyrimidin-4-ylamine

Reactants

N=C(N)c1ccc(F)cc1Cl
2-chlor-4-fluoro-benzamidine
N#CC(C#N)=Cc1ccc(Cl)cc1Cl
2-(2,4-dichloro-benzylidene)-malononitrile

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound, MS: m/e=396.8 (M+), was prepared from 2-chlor-4-fluoro-benzamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06867205B2uspto-grants-2005_03