Reaction #10708

Reaction equation

3,4-dimethoxythiophene

(S)-1,2-octanediol

→

2-n-hexyl-2,3-dihydro-thieno[3,4-b][1,4]dioxine

Conditions

Workup

1. 1
   Otherpurified to a purity of 99.69%
2. 2
   Othera specific rotation of −100°
3. 3
   Otherat 25° C.

Procedure

Chiral 2-n-hexyl-2,3-dihydro-thieno[3,4-b][1,4]dioxine was synthesized by transetherification of 3,4-dimethoxythiophene with (S)-1,2-octanediol and purified to a purity of 99.69% as described in INVENTION EXAMPLE 1. It was characterized by GC-MS and 1H-NMR-spectroscopy, and exhibited a specific rotation of −100° at 25° C. and 436 nm in hexane.

Source