Reaction #1068929

Reaction equation

sodium methylate

2-mercaptopyridine

2-amino-4-chloromethyl-6-methoxy-pyrimidine

→

2-Amino-4-methoxy 6-(pyridin-2-yl-thiomethyl)-pyrimidine

Solvents

methanol

water

Conditions

Workup

1. 1
   Temperatureis then maintained at 20°-25° C. for 1 hour
2. 2
   workup.STIRRINGthe mixture is stirred at 20°-25° C. for a further 2 hours
3. 3
   Otherthe precipitating crystalline product is separated
4. 4
   Otherdried

Procedure

18 g of 30% methanolic sodium methylate solution are added to a solution of 11.1 g of 2-mercaptopyridine in 100 ml of methanol, and stirring is then maintained at 20°-25° C. for 1 hour. To this solution are added portionwise 17.4 g of 2-amino-4-chloromethyl-6-methoxy-pyrimidine, and the mixture is stirred at 20°-25° C. for a further 2 hours. In further processing, the mixture is diluted with 1 liter of water, and the precipitating crystalline product is separated and dried. The yield is 22.5 g (91% of theory) of 2-amino-4-methoxy-6-(pyridin-2-yl-thiomethyl)-pyrimidine, m.p. 115°-116° C.

Source