Reaction #1068928

Reaction equation

4,5-dihydro-2-mercapto-thiazole

sodium methylate

2-amino-4-chloromethyl-6-methoxy-pyrimidine

→

2-Amino-4-methoxy-6-(4,5-dihydrothiazol-2-yl-thiomethyl)pyrimidine

Solvents

methanol

water

Conditions

Workup

1. 1
   Temperaturerefluxing
2. 2
   TemperatureAfter the solution has cooled
3. 3
   Otherthe product which precipitates
4. 4
   Otheris separated
5. 5
   Otherdried

Procedure

11.9 g of 4,5-dihydro-2-mercapto-thiazole are suspended in 100 ml of methanol, and to the suspension are added 18.0 g of 30% methanolic sodium methylate solution. To the formed clear solution are subsequently added 17.4 g of 2-amino-4-chloromethyl-6-methoxy-pyrimidine, and refluxing is carried out for 1 hour. After the solution has cooled, it is diluted with about 1 liter of water, and the product which precipitates is separated and dried. The yield is 22.5 g (88% of theory) of 2-amino-4-methoxy-6-(4,5-dihydrothiazol-2-yl-thiomethyl)-pyrimidine, m.p. 122°-124° C.

Source