Reaction #1068927

Reaction equation

dimethyldithiocarbamic acid sodium salt dihydrate

2-amino-4-chloromethyl-6-methoxypyrimidine

→

2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethylpyrimidine

Solvents

water

ethanol

Conditions

Workup

1. 1
   TemperatureAfter the mixture has been cooled
2. 2
   Otherthe product which has precipitated
3. 3
   Otheris separated
4. 4
   Otherdried

Procedure

18.5 g of dimethyldithiocarbamic acid sodium salt dihydrate and 17.4 g of 2-amino-4-chloromethyl-6-methoxypyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the mixture has been cooled, it is diluted with about 1 liter of water, and the product which has precipitated is separated and dried. The yield is 23.0 g (89% of theory) of 2-amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine, m.p. 118°-120° C.

Source