Reaction #1068926

Reaction equation

potassium ethylxanthogenate

2-amino-4-chloromethyl-6-methoxy-pyrimidine

→

2-Amino-4-methoxy-6-ethoxythiocarbonylthiomethylpyrimidine

Solvents

water

ethanol

Conditions

Workup

1. 1
   TemperatureAfter the reaction solution has cooled
2. 2
   Otherthe product which precipitates
3. 3
   Otheris separated
4. 4
   Otherdried

Procedure

16.0 g of potassium ethylxanthogenate and 17.4 g of 2-amino-4-chloromethyl-6-methoxy-pyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the reaction solution has cooled, it is diluted with about 1 liter of water, and the product which precipitates is separated and dried. The yield is 22.5 g (87% of theory) of 2-amino-4-methoxy-6-ethoxythiocarbonylthiomethyl-pyrimidine, m.p. 91°-93° C.

Source