Reaction #1068703

Reaction equation

2-chlorobenzaldehyde

2,4-diamino-6-hydroxypyrimidine

methyl 4-[2-(2,4,5-trimethylimidazol-1-yl)ethoxy]-3-oxobutanoate

→

title compound

Yield 3.0%

2-Amino-5-(2-chlorophenyl)-6-methoxycarbonyl-7-[2-(2,4,5-trimethylimidazol-1-yl)ethoxymethyl]-1,4,5,8-tetrahydro-4-oxopyrido[2,3-d]pyrimidine

Yield 3.0%

Conditions

Procedure

The title compound (110 mg) was prepared from 2-chlorobenzaldehyde (1.05 g), 2,4-diamino-6-hydroxypyrimidine (1.07 g) and methyl 4-[2-(2,4,5-trimethylimidazol-1-yl)ethoxy]-3-oxobutanoate (2.0 g) by the method of Example 1. M.p. 225°-227° C.

Source