Reaction #10686

ord-68a2a3cab0e14ea68b8e17f3298801c9

Reaction equation

O.O.[Cl][Sn][Cl]
tin(II) chloride dihydrate
O=[N+]([O-])c1cccc2c(O)ncc(Br)c12
Intermediate 137
O=[N+]([O-])c1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-nitroisoquinoline
→
Nc1cccc2c(O)ncc(Br)c12
title compound
Nc1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-aminoisoquinoline

Reactants

O.O.[Cl][Sn][Cl]
tin(II) chloride dihydrate
O=[N+]([O-])c1cccc2c(O)ncc(Br)c12
Intermediate 137
O=[N+]([O-])c1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-nitroisoquinoline

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

According to the method of Example 114, Step A, a reduction reaction with tin(II) chloride dihydrate was performed by using Intermediate 137 to obtain the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094789B2uspto-grants-2006_08