Reaction #10685

ord-d229cb2de4d94ee3acd656b3de7ca16d

Reaction equation

BrCCOC1CCCCO1
2-(2-bromoethoxy)tetrahydro-2H-pyran
Cl.N#Cc1cncc2cccc(O[C@H]3CC[C@H](N)CC3)c12
compound
Cl.N#Cc1cncc2cccc(O[C@H]3CC[C@H](N)CC3)c12
trans-4-[(4-cyano-5-isoquinolyl)oxy]cyclohexylamine hydrochloride
→
Cl.N#Cc1cncc2cccc(O[C@H]3CC[C@H](NCCO)CC3)c12
title compound
Cl.N#Cc1cncc2cccc(O[C@H]3CC[C@H](NCCO)CC3)c12
Trans-1-[(4-cyano-5-isoquinolyl)oxy]-4-[(2-hydroxyethyl)amino]cyclohexane hydrochloride

Reactants

BrCCOC1CCCCO1
2-(2-bromoethoxy)tetrahydro-2H-pyran
Cl.N#Cc1cncc2cccc(O[C@H]3CC[C@H](N)CC3)c12
compound
Cl.N#Cc1cncc2cccc(O[C@H]3CC[C@H](N)CC3)c12
trans-4-[(4-cyano-5-isoquinolyl)oxy]cyclohexylamine hydrochloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Othera deprotection reaction

Procedure

According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 134 to obtain the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094789B2uspto-grants-2006_08