Reaction #10683

ord-f848c0cd70984334a629a40bca364c48

Reaction equation

BrCCOC1CCCCO1
2-(2-bromoethoxy)tetrahydro-2H-pyran
Cl.N[C@H]1CC[C@@H](Nc2cccc3cnccc23)CC1
compound
Cl.N[C@H]1CC[C@@H](Nc2cccc3cnccc23)CC1
cis-N-(5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride
→
Cl.OCCN[C@H]1CC[C@@H](Nc2cccc3cnccc23)CC1
title compound
Cl.OCCN[C@H]1CC[C@@H](Nc2cccc3cnccc23)CC1
Cis-N-(5-isoquinolyl)-N′-(2-hydroxyethyl)-1,4-cyclohexanediamine hydrochloride

Reactants

BrCCOC1CCCCO1
2-(2-bromoethoxy)tetrahydro-2H-pyran
Cl.N[C@H]1CC[C@@H](Nc2cccc3cnccc23)CC1
compound
Cl.N[C@H]1CC[C@@H](Nc2cccc3cnccc23)CC1
cis-N-(5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Othera deprotection reaction

Procedure

According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 23 to obtain the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094789B2uspto-grants-2006_08