Reaction #1044

Reaction equation

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

Yield 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

Yield 94.2%

Solvents

ethyl acetate

Conditions

Workup

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   Filtrationfiltered
3. 3
   OtherThe residue obtained
4. 4
   Otherafter evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   Filtrationfiltered
7. 7
   OtherEvaporation of the solvent

Procedure

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

Source