Reaction #1037

ord-c52267ccc4ea462db1460373af993a7c

Reaction equation

O=C(O)CC(F)=C(F)F
3,4,4-trifiuoro-3-butenoic acid
O=C(Cl)C(=O)Cl
oxalyl chloride
→
O=C(Cl)CC(F)=C(F)F
3,4,4-trifluoro-3-butenoyl chloride

Reactants

O=C(O)CC(F)=C(F)F
3,4,4-trifiuoro-3-butenoic acid
O=C(Cl)C(=O)Cl
oxalyl chloride

Reagents

CN(C)C=O
DMF

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Reaction of 3,4,4-trifiuoro-3-butenoic acid (IV) with oxalyl chloride in the presence of DMF as a catalyst without any solvent to give 3,4,4-trifluoro-3-butenoyl chloride (V).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05723470uspto-grants-1998_03