Reaction #1034

Reaction equation

intermediate VII

4-bromo-3-chloro-3,4,4-trifluorobutanal

sodium borohydride

→

4-bromo-3-chloro-3,4,4-trifiuorobutanol

Conditions

Procedure

Alternatively, the intermediate VII can be reduced with sodium borohydride without isolation to give 4-bromo-3-chloro-3,4,4-trifiuorobutanol ((IX) in high yield; or by hydrolysis of 1,4-dibromo-2-chloro-1,1,2-trifiuorobutane (XVI) to give IX. Oxidation of IX with Jones reagent to give VIII in 85% yield.

Source