Reaction #1024

Reaction equation

Hydrogen chloride

N2 tert-butoxycarbonyl-N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide

→

desired product

Yield 100.0%

N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide hydrochloride

Yield 100.0%

Solvents

methylene chloride

Conditions

Workup

1. 1
   OtherAfter completion of the reaction
2. 2
   Otherthe methylene chloride was removed under reduced pressure
3. 3
   Otherthus obtaining a crude crystal
4. 4
   WashThe crude crystal was washed with acetone

Procedure

Hydrogen chloride gas was introduced into a solution containing 3.7 g of N2 -tert-butoxycarbonyl-N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide dissolved in 100 mL of methylene chloride for 1 hour at room temperature. After completion of the reaction, the methylene chloride was removed under reduced pressure, thus obtaining a crude crystal. The crude crystal was washed with acetone to afford 3.1 g of the desired product (yield: 100%). Melting point: 59°-63° C.

Source