Reaction #1005971

Reaction equation

2′-ethylsulfonylacetophenone

phenyltrimethylammonium tribromide

sodium thiosulfate

→

2-bromo-2′-ethylsulfonylacetophenone

Yield 164.0%

Solvents

THF

Conditions

Workup

1. 1
   Extractionthe mixture was extracted with t-butyl methyl ether
2. 2
   WashThe organic layer was washed with water
3. 3
   Dryingdried over anhydrous magnesium sulfate
4. 4
   Concentrationconcentrated under reduced pressure

Procedure

A mixture of 1.0 g of 2′-ethylsulfonylacetophenone, 1.86 g of phenyltrimethylammonium tribromide and 10 ml of THF was stirred at room temperature for 3 hours. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with t-butyl methyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure to obtain 1.37 g of 2-bromo-2′-ethylsulfonylacetophenone.

Source