Reaction #1005963

Reaction equation

2-amino-5-trifluoromethylpyridine

bromoethylacetate

→

(2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide

Conditions

Workup

1. 1
   Concentrationconcentrated under reduced pressure
2. 2
   Filtrationfiltered
3. 3
   WashThe resulting solid was washed with t-butyl methyl ether

Procedure

A mixture of 3.0 g of 2-amino-5-trifluoromethylpyridine and 7 ml of bromoethylacetate was stirred at 80° C. for 1 hour, and concentrated under reduced pressure. The resulting residue was suspended in a mixed solvent of acetonitrile and t-butyl methyl ether, and filtered. The resulting solid was washed with t-butyl methyl ether to obtain 2.46 g of (2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide.

Source