Reaction #1005959
ord-4aa3803c993a47ceb5f332510b78cda8
Reaction equation
(2-ethylsulfanylphenyl) (2-nitro-4-trifluoromethylbenzylidene)amine
triethyl phosphite
→
2-(2-ethylsulfanylphenyl)-6-trifluoromethyl-2H-indazole
Yield 78.9%
Reagents
None
Conditions
Temperature
100°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1Concentrationconcentrated under reduced pressure
Procedure
A mixture of 777 mg of (2-ethylsulfanylphenyl) (2-nitro-4-trifluoromethylbenzylidene)amine and 3 ml of triethyl phosphite was stirred at 100° C. for 15 minutes and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 558 mg of 2-(2-ethylsulfanylphenyl)-6-trifluoromethyl-2H-indazole (hereinafter, referred to as Compound of Present Invention 1).