Reaction #1005957

Reaction equation

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

Yield 95.2%

Solvents

methanol

water

Conditions

Workup

1. 1
   Extractionextracted twice with ethyl acetate
2. 2
   Washwashed with water
3. 3
   Dryingdried over anhydrous magnesium sulfate
4. 4
   FiltrationThe desiccant was filtered
5. 5
   Otherseparated
6. 6
   Otherthe solvent was evaporated off under reduced pressure

Procedure

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

Source