5-amino-3-methylisothiazole hydrochloride

Cc1cc(Nc2cc(N[C@H](CC(C)C)C(N)=O)ccc2C#N)sn1
Reaction #171987
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide
Yield 49.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@H](C)C(N)=O)ccc2C#N)sn1
Reaction #171990
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)propanamide
Yield 61.1%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
—
Reaction #171999
crude residue
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
—
Reaction #172002
crude residue
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@H](CC3CCCCC3)C(N)=O)ccc2C#N)sn1
Reaction #172007
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclohexylpropanamide
Yield 99.1%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
—
Reaction #172011
crude residue
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@H](CC(C)C)C(N)=O)cc(F)c2C#N)sn1
Reaction #172013
(R)-2-(4-cyano-3-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide
Yield 30.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
—
Reaction #172016
crude residue
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)c(F)cc2C(N)=O)sn1
Reaction #172018
titled compound
Yield 74.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2c(C(N)=O)ccc(N[C@H](CC(C)C)C(N)=O)c2F)sn1
Reaction #172020
titled compound
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
—
Reaction #172022
crude residue
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
—
Reaction #172024
crude residue
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
COC[C@@H](CNc1ccc(C#N)c(Nc2cc(C)ns2)c1)NC(=O)OC(C)(C)C
Reaction #172026
(R)-tert-butyl 1-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-methoxypropan-2-ylcarbamate
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
COC[C@@H](Nc1cc(Nc2cc(C)ns2)c(C#N)cc1F)C(N)=O
Reaction #172035
(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-methoxypropanamide
Yield 27.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@@H](C(N)=O)C3CC3)c(F)cc2C#N)sn1
Reaction #172053
(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-2-cyclopropylacetamide
Yield 39.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(NC3CCCCNC3=O)ccc2C#N)sn1
Reaction #172056
2-(3-methylisothiazol-5-ylamino)-4-(2-oxoazepan-3-ylamino)benzonitrile
Yield 159.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@H](Cc3c[nH]c4ccccc34)C(N)=O)ccc2C#N)sn1
Reaction #172061
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-(1H-indol-3-yl)propanamide
Yield 96.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@H](Cc3ccccn3)C(N)=O)c(F)cc2C#N)sn1
Reaction #172065
(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-(pyridin-2-yl)propanamide
Yield 38.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(NC(CC(F)(F)F)C(N)=O)c(F)cc2C#N)sn1
Reaction #172071
2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-4,4,4-trifluorobutanamide
Yield 99.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
Cc1cc(Nc2cc(N[C@H](Cc3cccs3)C(N)=O)ccc2C#N)sn1
Reaction #172076
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-(thiophen-2-yl)propanamide
Yield 33.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09
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