Intermediate 4

COc1cc(CC(=O)Nc2cccc(-c3ccccc3)c2)ccc1OCCNC(=O)OC(C)(C)C
Reaction #7168
4-[2-(tert-butoxycarbonylamino)ethoxy]-3-methoxy-N-(3-phenylphenyl)phenylacetamide
Yield 77.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2006_08
COc1cc(CC(=O)Nc2cccc(/C=C/c3cccc(C)c3)c2)ccc1OCCNC(=O)OC(C)(C)C
Reaction #7178
4-[2-(tert-butoxycarbonylamino)-ethoxy]-3-methoxy-N-[3-[(E)-2-(3-methylphenyl)vinyl]phenyl]phenylacetamide
Yield 152.4%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2006_08
COc1cc(CC(=O)Nc2cccc(-c3ccccc3)c2)ccc1OCCNC(=O)OC(C)(C)C
Reaction #915584
DOI: 10.1039/C8SC04228DTest data from https://doi.org/10.1039/C8SC04228D