Reaktion #999335

Reaktionsgleichung

4-methyl-3-nitro-benzoic acid

HOBt

N-ethylpiperazine

→

(4-ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone

Ausbeute 95.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with aqueous ammonium chloride solution
2. 2
   Trocknensubsequently dried over sodium sulfate
3. 3
   FiltrationAfter filtering sodium sulfate
4. 4
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

To 4-methyl-3-nitro-benzoic acid (730 mg, 4.03 mmol), WSCI (930 mg, 4.85 mmol), HOBt (110 mg, 0.674 mmol) and N-ethylpiperazine (608 μl, 4.79 mmol), dichloromethane (8 ml) was added, followed by stirring for 13 hours. The reaction mixture was washed with aqueous ammonium chloride solution, and subsequently dried over sodium sulfate. After filtering sodium sulfate, the filtrate was concentrated under reduced pressure, to obtain (4-ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone (1.06 g, 95%).

Quelle