Reaktion #9985

Reaktionsgleichung

(S)-1,2,3,5,6,7,8,8a-octahydroindolizin-5,7-dione

pyrrolidine

→

pyrrolidine

title compound

(S)-7-(1-Pyrrolidinyl)-1,2,3,5,8,8a-hexahydroindolizin-5-one

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAt the end of this time, the reaction mixture was concentrated by distillation under reduced pressure
2. 2
   Sonstigeto remove solvents

Vorschrift

(S)-1,2,3,5,6,7,8,8a-octahydroindolizin-5,7-dione (117 mg (0.76 mmol), prepared as described in 3)) was dissolved in ethanol (1.2 ml). To the solution was added pyrrolidine (128 μl, 1.53 mmol), and the resulting mixture was allowed to stand at room temperature for 5 minutes. At the end of this time, the reaction mixture was concentrated by distillation under reduced pressure to remove solvents and any excess of pyrrolidine, to give the title compound (160 mg) as a light yellow powder (yield quantitative).

Quelle