Reaktion #998322

Reaktionsgleichung

4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyridin-2-amine

1-chloro-4-phenylphthalazine

tBuOH

→

N-(4-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-4-phenyphthalazin-1-amine

Lösungsmittel

diethyl ether

sodium carbonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solids were filtered
2. 2
   Waschenwashed with water, diethyl ether and air
3. 3
   Sonstigedried

Vorschrift

To 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyridin-2-amine (0.070 g, 0.24 mmol) and 1-chloro-4-phenylphthalazine (0.048 g, 0.20 mmol) was added tBuOH (1.0 mL). The resulting mixture was heated at 100° C. in a sealed tube for 16 hours. The reaction was diluted with diethyl ether and saturated sodium carbonate and vigorously shaken. The resulting solids were filtered and washed with water, diethyl ether and air dried to yield N-(4-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-4-phenyphthalazin-1-amine as an off-white solid. MS m/z=497 [M+H]+. Calc'd for C31H24N6O: 496.58.

Quelle