Reaktion #998237

Reaktionsgleichung

4-(4-methoxybenzylthio)-5-bromopyridin-2-amine

Benzoyl isothiocyanate

EtOAc

→

desired product

Ausbeute 76.0%

1-(4-(4-methoxybenzylthio)-5-bromopyridin-2-yl)-3-benzoylthiourea

Ausbeute 76.0%

Lösungsmittel

THF

—

hexanes

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigedried

Vorschrift

4-(4-methoxybenzylthio)-5-bromopyridin-2-amine (7.45 g, 22.9 mmol) was dissolved in THF (80 mL). Benzoyl isothiocyanate (3.4 ml, 25 mmol) was added, and the reaction was stirred overnight at ambient temperature. The solution was diluted in 9:1 hexanes:EtOAc and stirred for 5 minutes, then filtered and dried to provide the desired product (8.5 g, 76% yield) as a brown solid.

Quelle