Reaktion #998009

Reaktionsgleichung

sodium methoxide

4-(1,1,1-trifluoromethyl)-2-fluoro-benzaldehyde

Water

→

2-Methoxy-4-(trifluoromethyl)benzaldehyde

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture heated
2. 2
   Temperaturunder reflux for 2 h
3. 3
   Extraktionthe mixture extracted with ethyl acetate
4. 4
   SonstigeThe organics were dried
5. 5
   Sonstigeevaporated under reduced pressure
6. 6
   Sonstigeto give a residue that
7. 7
   Sonstigewas purified by chromatography on silica eluting with isohexane/diethylether 3:1, yield 3.18 g

Vorschrift

A solution of sodium methoxide (25% wt in methanol, 50 ml) was added to a solution of (4-(1,1,1-trifluoromethyl)-2-fluoro-benzaldehyde (5.0 g) in methanol (50 ml) and the mixture heated under reflux for 2 h. Water (200 ml) was added and the mixture extracted with ethyl acetate. The organics were dried and evaporated under reduced pressure to give a residue that was purified by chromatography on silica eluting with isohexane/diethylether 3:1, yield 3.18 g.

Quelle