Reaktion #998005

Reaktionsgleichung

Water

4-(1,1,1-trifluoromethyl)-2-fluoro-benzaldehyde

potassium carbonate

3-cyanophenol

→

3-[2-Formyl-5-(trifluoromethyl)phenoxy]benzonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthen cooled
2. 2
   Extraktionthe mixture extracted with ethyl acetate
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated under reduced pressure
5. 5
   SonstigeThe residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1
6. 6
   Sonstigeto give a colourless oil, yield 2.0 g

Vorschrift

A mixture of 4-(1,1,1-trifluoromethyl)-2-fluoro-benzaldehyde (2.5 g), potassium carbonate (1.79 g) and 3-cyanophenol (1.54 g) in DMF (20 ml) was heated at 110° C. for 2 h then cooled. Water (200 ml) was added and the mixture extracted with ethyl acetate, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1 to give a colourless oil, yield 2.0 g.

Quelle