Reaktion #9975

Reaktionsgleichung

5-Ethoxycarbonyl-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene

sodium hydroxide

→

title compound

Ausbeute 91.2%

5-Carboxy-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene

Ausbeute 91.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAt the end of this time, ethanol was removed by distillation under reduced pressure
2. 2
   workup.ADDITIONTo the reaction residue was added water
3. 3
   FiltrationThe precipitated crystals were collected by filtration

Vorschrift

5-Ethoxycarbonyl-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene (15.17 g (46.3 mmol), prepared as described in 1)) was dissolved in ethanol (150 ml). To the solution was added an aqueous solution of 1 N sodium hydroxide (93 ml, 93 mmol), and the resulting mixture was stirred at 100° C. for 30 minutes. At the end of this time, ethanol was removed by distillation under reduced pressure. To the reaction residue was added water, and then an aqueous solution of 1 N hydrochloric acid (93 ml). The precipitated crystals were collected by filtration, to give the title compound (12.64 g) as a pale brown powder (yield 91%).

Quelle