Reaktion #997401

Reaktionsgleichung

Hydroxylamine hydrochloride

(E)-3-(dimethylamino)-1-[4-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl]-2-propen-1-one

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title compound

Ausbeute 24.9%

5-[4-(6-Iodoimidazo[1,2-a]pyridin-2-yl)phenyl]isooxazole

Ausbeute 24.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby refluxing for 2 hours
2. 2
   SonstigeThe solvent was evaporated
3. 3
   Sonstigethe residue was purified through silica gel chromatography (dichloromethane:methanol=97:3)

Vorschrift

Hydroxylamine hydrochloride (53 mg) was added to a solution (5 mL) of (E)-3-(dimethylamino)-1-[4-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl]-2-propen-1-one (104 mg) in ethanol, followed by refluxing for 2 hours. The solvent was evaporated, and the residue was purified through silica gel chromatography (dichloromethane:methanol=97:3), to thereby yield the title compound (24 mg).

Quelle