Reaktion #9969

Reaktionsgleichung

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine

4-formylpyridine

magnesium sulfate

→

title compound

Ausbeute 100.7%

(±)-7-(Pyridin-4-yl)methyleneamino-1,2,3,5,6,7,8,8a-octahydroindolizine

Ausbeute 100.7%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAt the end of this time, the reaction mixture was filtered
2. 2
   Sonstigeto remove the catalyst
3. 3
   Einengenthe filtrate was concentrated by evaporation under reduced pressure

Vorschrift

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine (4.91 g (35.0 mmol), prepared as described in 1)) was dissolved in toluene (95 ml). To the solution were added 4-formylpyridine (3.34 ml, 35.0 mmol) and anhydrous magnesium sulfate (3.75 g, 31.2 mmol), and the resulting mixture was stirred at 70° C. for 3 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (8.08 g) as a pale yellow oil (yield quantitative).

Quelle