Reaktion #996569

Reaktionsgleichung

product

4-[3-Bromo-5-isopropoxy-4-(4-nitro-benzyloxy)-phenyl]-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile

acetic acid

→

4-(3-Bromo-4-hydroxy-5-isopropoxy-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,-7,8-hexahydro-quinoline-3-carbonitrile

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   workup.ADDITIONThe mixture was diluted with EtOAc
3. 3
   Waschenwashed with sat. aq. NaHCO3
4. 4
   TrocknenThe organic layer was dried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo

Vorschrift

To a solution of the product isolated in step c (750 mg) and acetic acid (1.5 ml) in THF (50 ml) was added zinc dust (1.5 g) under vigorous stirring. The mixture was stirred for 2 h and then filtered. The mixture was diluted with EtOAc and washed with sat. aq. NaHCO3. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.

Quelle