Reaktion #9962

Reaktionsgleichung

6-Amino-5-chloro-2-methylbenzoxazole

sulfuryl chloride

→

6-Amino-5,7-Dichloro-2-Methylbenzoxazole

Lösungsmittel

ethyl acetate

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   FiltrationAfter 1 hour the precipitate was filtered off
3. 3
   Waschenwashed with ether
4. 4
   Sonstigeair-dried

Vorschrift

6-Amino-5-chloro-2-methylbenzoxazole (10 g, 54.76 mMole) was dissolved in ethyl acetate (150 mL). At room temperature and with good stirring, sulfuryl chloride (8.8 mL, 109.52 mMole) was added drop by drop over a 20-minute period. As the addition proceeds, additional ethyl acetate (350 mL) was added to keep the mixture stirring. After 1 hour the precipitate was filtered off, washed with ether and air-dried. Yield 10.5 g.

Quelle