Reaktion #994633

ord-2dc9aed2ba0c467cbdee45da8be596b5

Reaktionsgleichung

COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@H](COC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21
Fmoc-Ser(tBu)-Tyr(tBu)-OMe
NCCN(CCN)CCN
TAEA
→
C=CCOC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](N)COC(C)(C)C
crude product
Ausbeute 88.0%
C=CCOC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](N)COC(C)(C)C
Ser(tBu)-Tyr(tBu)-OAllyl
Ausbeute 88.0%

Edukte

COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@H](COC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21
Fmoc-Ser(tBu)-Tyr(tBu)-OMe
NCCN(CCN)CCN
TAEA

Reagenzien

Keine

Lösungsmittel

CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

According to the general procedure for Fmoc-cleavage, 9 g Fmoc-Ser(tBu)-Tyr(tBu)-OMe, 22 ml TAEA in ethyl acetate yielded 4.7 g of crude product (yield based on HPLC: 88%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08013117B2uspto-grants-2011_09