Reaktion #994385

Reaktionsgleichung

Intermediate ( 4a )

4′-(2-Butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

NH2OH.HCl

pyridine

→

intermediate ( 4b )

Ausbeute 93.6%

4′-[2-Butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

Ausbeute 93.6%

Lösungsmittel

water

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   Sonstigedried

Vorschrift

Intermediate (4a) (12.1 g, 26.7 mmol) and NH2OH.HCl (2.4 g, 34.7 mmol) were combined in 80 mL water and 160 mL pyridine and stirred at room temperature overnight. Water (80 mL) was added and the mixture was stirred for 1 hour. The precipitate was filtered and dried to yield 11.7 g of intermediate (4b), which was used in the next step without further purification.

Quelle