Reaktion #992706

Reaktionsgleichung

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

Lösungsmittel

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   Sonstigethe solid was isolated by filtration
4. 4
   Sonstigetwice recrystallized from isopropanol
5. 5
   WaschenThe product was rinsed with isopropanol, suction
6. 6
   Sonstigedried
7. 7
   Sonstigevacuum dried in an oven overnight

Vorschrift

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

Quelle