Reaktion #992014

Reaktionsgleichung

1-(thiazin-2-yl)-2-amino-6-(α-methylenebenzyl)benzimidazole

N-chlorosuccinimide

→

1-(Thiazin-2-yl)-2-amino-6-(α-chloromethylenebenzyl)benzimidazole

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   workup.ADDITIONthe filtrate was diluted with water
3. 3
   Einengenconcentrated to a volume of about 25 ml
4. 4
   SonstigeThe precipitate which formed
5. 5
   Filtrationwas collected by filtration
6. 6
   Sonstigedried

Vorschrift

A solution of 500 mg. of 1-(thiazin-2-yl)-2-amino-6-(α-methylenebenzyl)benzimidazole in 50 ml. of tetrahydrofuran containing 250 mg. of N-chlorosuccinimide was stirred at room temperature for sixteen hours. The reaction mixture was filtered, and the filtrate was diluted with water and then concentrated to a volume of about 25 ml. The precipitate which formed was collected by filtration, dried, and identified as 140 mg. of 1-(thiazin-2-yl)-2-amino-6-(α-chloromethylenebenzyl)benzimidazole.

Quelle