Reaktion #990324

Reaktionsgleichung

hydrochloric acid

7,10-dichloro-2-methoxypyrido[3,2-b]quinoline

4-diethylaminobutylamine

phenol

→

desired product

7-Chloro-10-[(4-diethylaminobutyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride

Lösungsmittel

ethanol

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 2.8 g
2. 2
   TemperaturThe reaction is cooled
3. 3
   workup.ADDITIONthis mixture is poured into a mixture of 200 ml
4. 4
   SonstigeThe yellow solic is collected
5. 5
   Sonstigeair-dried
6. 6
   Sonstigerecrystallized from ethanol

Vorschrift

A mixture of 2.8 g. of 7,10-dichloro-2-methoxypyrido[3,2-b]quinoline, 1.5 g. of 4-diethylaminobutylamine and 6.5 g. of phenol is heated at 100° C. for 3 hours. The reaction is cooled, 20 ml. of ethanol is added and this mixture is poured into a mixture of 200 ml. of acetone and 2.5 ml. of concentrated hydrochloric acid. The yellow solic is collected, air-dried and recrystallized from ethanol, giving the desired product, mp. 246°-274° C. (dec.).

Quelle