Reaktion #989363

Reaktionsgleichung

1H-Indazole-3-carboxylic acid

1-Isopropyl-piperidin-4-ylamine hydrochloride

BOP-Cl

water

→

1H-Indazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

Lösungsmittel

DMF

NEt3

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationwas filtered through a chem elut® cartridge by elution with ethyl acetate
2. 2
   Einengenconcentrated under reduced pressure
3. 3
   SonstigeThe residue was directly subjected to the subsequent alkylation reaction without further purification

Vorschrift

To a solution of 300 mg 1H-Indazole-3-carboxylic acid in 3 mL DMF and 1 mL NEt3, 398 mg 1-Isopropyl-piperidin-4-ylamine hydrochloride and 471 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. After the addition of 5 mL water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The residue was directly subjected to the subsequent alkylation reaction without further purification. Yield: 340 mg.

Quelle