Reaktion #989362

Reaktionsgleichung

1H-Indazole-3,5-dicarboxylic acid 5-methyl ester

BOP-Cl

1-Isopropyl-piperidin-4-ylamine hydrochloride

water

→

3-(1-Isopropyl-piperidin-4-ylcarbamoyl)-1H-indazole-5-carboxylic acid methyl ester

Lösungsmittel

DCM

NEt3

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionwas extracted with DCM (3×50 mL)
2. 2
   TrocknenThe combined organic layers were dried over MgSO4
3. 3
   SonstigeAfter removal of the solvent under reduced pressure the crude product
4. 4
   Sonstigewas used without further purification

Vorschrift

To a solution of 1 g 1H-Indazole-3,5-dicarboxylic acid 5-methyl ester in 8 mL DCM, 2.5 mL NEt3, 1.15 g BOP-Cl and 0.98 g 1-Isopropyl-piperidin-4-ylamine hydrochloride were added at RT. The mixture was stirred for 3 h. After addition of 20 mL of water the reaction mixture was extracted with DCM (3×50 mL). The combined organic layers were dried over MgSO4. After removal of the solvent under reduced pressure the crude product was used without further purification.

Quelle