Reaktion #989127

Reaktionsgleichung

ethyl 2-methylthiazole-4-carboxylate

N-bromosuccinimide

azo-bis-(isobutyronitrile)

→

ethyl 2-bromomethylthiazole-4-carboxylate

Ausbeute 44.8%

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 18 h
2. 2
   FiltrationThe mixture was filtered

Vorschrift

A solution of ethyl 2-methylthiazole-4-carboxylate (5.0 g, 29 mmol), N-bromosuccinimide (6.2 g, 35 mmol) and azo-bis-(isobutyronitrile) (480 mg, 2.9 mmol) in carbon tetrachloride (150 ml) was heated at reflux for 18 h. The mixture was filtered and reduced. Chromatography (20% EtOAc/80% hexanes and 30% EtOAc/70% hexanes) afforded ethyl 2-bromomethylthiazole-4-carboxylate (3.25 g, 44%).

Quelle