Reaktion #987463

ord-5b17f4406c7840caa11cd92bd3f2d568

Reaktionsgleichung

Cc1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)ccc1N
N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide
F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
PhCH2COOH PyBOP
→
Cc1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)ccc1NCc1ccccc1
{[(5-chloro(2-thienyl))sulfonyl]amino}-N-{3-methyl-4-[benzylamino]phenyl}carboxamide

Edukte

Cc1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)ccc1N
N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide
F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
PhCH2COOH PyBOP

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

1.0 equivalent of N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide was treated with 1.0 equivalent of PhCH2COOH/PyBOP to give X═CH2, {[(5-chloro(2-thienyl))sulfonyl]amino}-N-{3-methyl-4-[benzylamino]phenyl}carboxamide. ES-MS (M+H)+=464, 466 (Cl).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07358257B2uspto-grants-2008_04