Reaktion #987430

Reaktionsgleichung

3-(1H-Imidazol-4-yl)-propionic acid

trimethyl chlorosilane

→

3-(1H-imidazol-4-yl)-propionic acid methyl ester

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated under reduced pressure
2. 2
   SonstigeThe residue was evaporated from MeOH (1×) and from toluene (1×)

Vorschrift

To a suspension of 3-(1H-Imidazol-4-yl)-propionic acid (700 mg) in MeOH (20 mL) was added trimethyl chlorosilane (2 mL) dropwise. The mixture was stirred for 6 h at RT and concentrated under reduced pressure. The residue was evaporated from MeOH (1×) and from toluene (1×) to give crude 3-(1H-imidazol-4-yl)-propionic acid methyl ester as its hydrochloride salt (950 mg, colorless solid), which was used without further purification in the next step.

Quelle