Reaktion #986070

Reaktionsgleichung

4-(2-hydroxyethyl)phenol

potassium carbonate

tert-butyl bromoacetate

→

desired product

Ausbeute 92.8%

Tert-butyl [4-(2-hydroxyethyl)phenoxy]acetate

Ausbeute 92.8%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 16 hours
2. 2
   SonstigeThe solvent was evaporated under reduced pressure
3. 3
   workup.DISSOLUTIONThe residue was dissolved in EtOAc
4. 4
   Waschenwashed with brine and water
5. 5
   Trocknendried with MgSO4
6. 6
   Sonstigeevaporated under reduced pressure

Vorschrift

A mixture of 4-(2-hydroxyethyl)phenol (3.8 ml, 25.834 mmol) was dissolved in acetonitrile (25 ml), potassium carbonate (7.085 g, 51.267 mmol) and tert-butyl bromoacetate (5.000 g, 25.834 mmol) was boiled under reflux for 16 hours. The solvent was evaporated under reduced pressure. The residue was dissolved in EtOAc and washed with brine and water, dried with MgSO4 and evaporated under reduced pressure to give the desired product was obtained (6.00 g, yield 92.8%).

Quelle