Reaktion #985766

Reaktionsgleichung

2-bromo-4-trifluoromethyl-phenol

ethyl bromo-acetate

→

ethyl (2-bromo4-trifluoromethyl-phenoxy)-acetate

Lösungsmittel

EtOAc

Hünig base

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenphase was washed with water, saturated aqueous sodium bicarbonate and saturated aqueous NaCl
2. 2
   Trocknendried over magnesium sulphate
3. 3
   Sonstigeevaporated down i
4. 4
   SonstigeColumn chromatography (silica gel, gradient dichloromethane/MeOH 100:0→19:1) yielded the product

Vorschrift

A solution of 2.650 g (11.000 mmol) 2-bromo-4-trifluoromethyl-phenol and 1.47 mL 13.20 mmol) ethyl bromo-acetate in 20 mL Hünig base was stirred for 5 h at 120° C. The reaction mixture was diluted with EtOAc and the org. phase was washed with water, saturated aqueous sodium bicarbonate and saturated aqueous NaCl, dried over magnesium sulphate and evaporated down i. vac. Column chromatography (silica gel, gradient dichloromethane/MeOH 100:0→19:1) yielded the product.

Quelle