Reaktion #985694

Reaktionsgleichung

sodium bicarbonate

9-hydroxyfluorene-9-carboxlic acid

butanol

sulfuric acid

→

butyl 9-hydroxyfluorene-9-carboxylate

Ausbeute 80.0%

Lösungsmittel

water

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was heated
2. 2
   Sonstigewas separated by a water segregator
3. 3
   SonstigeAt the end of the reaction
4. 4
   Waschenwashed with saturated saline
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   Trocknendried over anhydrous sodium sulfate
7. 7
   SonstigeRemoving the solvent
8. 8
   Sonstigegave the product with a yield of 80%

Vorschrift

To a reactor were added 0.05 mol of 9-hydroxyfluorene-9-carboxlic acid, 0.075 mol of butanol, 40 ml of toluene and 0.4 ml of concentrated sulfuric acid. The reaction was heated to reflux for 6 hrs, while water was separated by a water segregator. At the end of the reaction, the reaction mixture was neutralized with sodium bicarbonate, washed with saturated saline, extracted with ethyl acetate, and dried over anhydrous sodium sulfate. Removing the solvent gave the product with a yield of 80%.

Quelle