Reaktion #985327

Reaktionsgleichung

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

Lösungsmittel

DCE

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated in vacuo
2. 2
   Sonstigepurified by prep

Vorschrift

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspended in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound.

Quelle